Difference Between Mullerian Anomalies Agenesis and Androgen Insensitivity

What is Mullerian Anomalies agenesis and androgen insensitivity?

Müllerian agenesis is a rare medical condition that affects females. In this condition, the vagina and the uterus do non develop fully in females who have normal ovarian function and normal external ballocks. Androgen insensitivity is a genetic condition that involves hormonal resistance because of androgen receptor dysfunction.


Both are developmental defects resulting in primary amenorrhea.

Mullerian Anomalies

Müllerian agenesis (Mayer‐Rokitansky‐Küster‐Hauser syndrome) is acquired by inadequate evolution of embryo of the müllerian duct, with resultant atresia of the vagina, uterus, or both. The passage or canal of the vagina is significantly shortened and appears as a small low underneath the urethra.

Androgen Insensitivity

Androgen insensitivity syndrome (AIS) is when a human who is genetically a human being (possessing one X and ane Y chromosome) is balky to androgens (male hormones) person who is genetically male (who has ane X and one Y chromosome) is resistant to male hormones (called androgens). As a result, the private has some of the physical traits of a female person, but the genetic features of a man.

Difference between Mullerian Anomalies and Androgen Insensitivity


Mullerian Anomalies

Müllerian anomalies impact up to four% of women. The anomaly is basically a ‘congenital disorder’ which means that this problem occurs at the time of fetal development and is nowadays at birth.

Müllerian anomalies occur when müllerian ducts develop abnormally, which can get a reason to cause disruption in the evolution of the full reproductive organs – fallopian tubes, cervix, uterus, and upper two/3rd of the vagina

Androgen Insensitivity

Androgen insensitivity syndrome occurs when trunk is unable to use androgen hormones.  Individuals with this condition are usually men, with one X chromosome and one Y chromosome in every single cell. This condition affects the sexual development prior to nascence and at the time of puberty. Considering people with this status are not able to be responsive to specific male sex hormones termed as androgens. They possess female external sex features of both men and women sexual development.

Popular:   Difference Between NDRI and SSRI

Individuals with this condition take the external sexual activity characteristics of women, just lack a uterus and hence do non have monthly bicycle and are not able to become significant (infertile).


Mullerian Anomalies

Some causes may be hereditary and some may exist attributed to a random cistron mutation or developmental defect.

Androgen Insensitivity

It is caused by the genetic alteration or mutations on the X chromosome that means the body is not able to respond to testosterone either completely or partially.


Mullerian Anomalies

  • Infertility
  • No menstrual cycle
  • Infertility
  • Recurrent miscarriage.
  • Preterm labour
  • Pelvic pain
  • Difficulty with intercourse

Androgen Insensitivity

  • No periods
  • Breasts evolution
  • Growth spurts as normal
  • Slightly taller than a usual girl
  • No pubic hair or very lilliputian pubic pilus


Mullerian Anomalies

  • Pelvic ultrasound
  • Pelvic magnetic resonance imaging (MRI)
  • Hysterosalpingography
  • Hysteroscopy
  • Vaginoscopy
  • Laparoscopy

Androgen Insensitivity

  • Genetic testing
  • Pelvic ultrasound
  • Claret test to appraise the testosterone levels – luteinizing hormone (LH) and follicle-stimulating hormone (FSH)


The points of divergence between Mullerian Anomalies and Androgen Insensitivity have been summarized as below:


Why ovaries are normal in Mullerian Anomalies agenesis?

Considering ovaries don’t develop from the primordial anlage of the female person reproductive tract (Müllerian ducts), impacted individuals may accept normal secondary sexual traits but are infertile because of the absenteeism of functional uterus. However, becoming a parent is possible by means of gestational surrogates.

Can you go pregnant with Mullerian Anomalies agenesis?

Yes. Assisted reproductive procedures with awarding of a gestational carrier (surrogate) have been reported to be victorious for women with müllerian agenesis. Female person offspring or kid of women who conceived by assisted reproductive technique usually have normal fallopian tubes, the uterus, the vagina, although familial aggregates of müllerian have been reported

Popular:   Difference Between Computer Vision and Pattern Recognition

How is vaginal agenesis diagnosed?

Vaginal agenesis, in some cases can exist diagnosed past concrete examination. Other tests include an ultrasound (to assess whether ovaries and uterus are present and location of your kidneys), an 10-ray (to check skeletal anomalies), or MRI (to check reproductive tract and kidneys).

Blood tests may besides be washed to appraise chromosomes and evaluate hormone levels

How is MRKH diagnosed?

MRKH or Mayer–Rokitansky–Küster–Hauser syndrome or vaginal agenesis are the same. The diagnosis involves physical examination. Other tests include an ultrasound (to assess whether ovaries and uterus are present and location of your kidneys), an 10-ray (to check skeletal anomalies), or MRI (to check reproductive tract and kidneys).

Blood tests may also be done to assess chromosomes and evaluate hormone levels

What is Mullerian Anomalies syndrome?

Müllerian duct anomalies syndrome includes structural anomalies triggered by errors in müllerian-duct evolution at the time of spatial distribution of cells during the embryonic development of an organism called embryonic morphogenesis. Factors that precipitate include genetics, and maternal exposure to teratogens.

Do people with MRKH syndrome have periods?

No. People with MRKH syndrome typically do not get monthly menstrual cycles since their reproductive organs are either compromised or absent

  • Author
  • Recent Posts


Email This Post Email This Postal service : If you like this commodity or our site. Please spread the word. Share it with your friends/family.

Source: http://www.differencebetween.net/science/health/difference-between-mullerian-anomalies-agenesis-and-androgen-insensitivity/